Postdoctoral Researcher in AI/ML-driven LC-MS for biopharmaceutical characterization

HES-SO Valais-Wallis

Rue de l'Industrie 23, 1950 SionFestanstellungVeröffentlicht 21.7.2026

Über den Job

The Mass Spectrometry and Separation Sciences Laboratory (MS3L) at the HES-SO Valais-Wallis is seeking a highly motivated and skilled Postdoctoral Researcher with expertise in liquid chromatography high-resolution mass spectrometry (LC-HRMS), proteomics and biotherapeutic characterization. The successful candidate will combine hands-on Orbitrap-based analysis with active participation in the development of AI/ML-assisted data processing, working in a multidisciplinary team alongside software engineers and industry partners. The position is within the Institute of Systems Engineering at the School of Engineering, Energypolis campus.

Aufgaben

Operate and maintain the LC-Orbitrap system, including method setup and routine troubleshooting
Develop and execute sample-preparation protocols for intact-mass and peptide-mapping analysis of monoclonal antibodies and related biopharmaceuticals
Perform HRMS data processing, interpretation and reporting, including multi-attribute method (MAM) and critical-quality-attribute workflows
Analyze host cell protein (HCP) profiles
Collaborate with software engineers to design, test and validate AI/ML tools for LC-HRMS data analysis and pipeline optimization
Engage with industry partners to translate methods into application-ready workflows
Contribute to manuscripts, project reports and scientific presentations

Profil

PhD in Analytical Chemistry, Biochemistry or a related field
Demonstrated hands-on experience with LC-HRMS operation, in particular Orbitrap mass spectrometers
Experience with protein/biopharmaceutical sample preparation and LC-MS data analysis
Working proficiency in at least one scripting language (R, Python or similar) for data handling and analysis
Strong assets include: experience with antibody characterization; familiarity with MAM workflows and HCP analysis; experience applying AI/ML methods to analytical data; experience with nano/micro LC instrumentation
Strong organizational, communication and collaborative skills
Proficiency in English (spoken and written) is required; French and German language skills are a plus

Rahmenbedingungen

Employment: 80%
Place of work: Sion
Starting date: November 2026 or upon agreement
Contract duration: 2 years
For further information: Saša Miladinovic, associate professor UAS, sasa.miladinovic(a)
Please submit your complete application documents (CV, motivation letter, diplomas and certificates) by 21 August 2026 by clicking on the Apply button. Only online applications will be considered.

Benefits

Stimulating applied research addressing real-world challenges in AI/ML for biopharmaceutical analysis
Close collaboration with expert scientists, engineers and industry partners
Access to state-of-the-art mass spectrometry instrumentation and computational tools
Excellent teaching and laboratory facilities in a modern analytical chemistry environment, with the opportunity to develop teaching and student mentoring experience
A position based in Sion, a picturesque town in the heart of the Alps and the sunny capital of Valais

Skills

ProteomikBiotherapeutika-CharakterisierungAI/ML (Machine Learning)PhD in Analytischer Chemie/BiochemieWissenschaftliches PublizierenEnglischkenntnisse

Postdoctoral Researcher in AI/ML-driven LC-MS for biopharmaceutical characterization

Über den Job

Über den Job

Aufgaben

Profil

Rahmenbedingungen

Benefits

Skills

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